Ferguson Jessica J A, Oldmeadow Christopher, Bentley David, Garg Manohar L
Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.
Clinical Research Design, Information Technology and Statistical Support Unit, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2308, Australia.
Antioxidants (Basel). 2022 Aug 11;11(8):1560. doi: 10.3390/antiox11081560.
Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (−1.19 nmol/mL, 95%CI −1.62, −0.75, p < 0.001) and 12 weeks (−1.35 nmol/mL, 95%CI −1.74, −0.96, p < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (p < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (−0.25 g/L, 95%CI −0.39, −0.11; p < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; p < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases.
氧化应激是衰老过程中的关键生理现象，在与年龄相关的慢性疾病的发展中起主要作用。本研究调查了一种富含多酚的膳食补充剂（含有马尾松树皮提取物（PMBE））对健康老年人的抗氧化作用。在一项双盲、安慰剂对照临床试验中，参与者被随机（1:1比例）分配，接受每天50毫升的膳食补充剂，其中一组含安慰剂（0毫克PMBE），另一组含PMBE（1322毫克PMBE），为期12周。主要结局指标是空腹血浆丙二醛（MDA）浓度，次要结局指标是血浆炎症标志物。与基线相比，服用PMBE 6周（-1.19纳摩尔/毫升，95%CI -1.62，-0.75，p<0.001）和12周（-1.35纳摩尔/毫升，95%CI -1.74，-0.96，p<0.001）后，MDA浓度显著降低。服用安慰剂后，MDA没有显著变化。与安慰剂相比，服用PMBE后6周和12周时的MDA水平显著更低（p<0.001）。在PMBE组的12周时，与安慰剂相比，纤维蛋白原浓度显著降低（-0.25克/升，95%CI -0.39，-0.11；p<0.0001），白细胞介素-6显著升高（0.30皮克/毫升，95%CI 0.02，0.59；p<0.05）。富含多酚的膳食补充剂中的PMBE可降低健康老年人的氧化应激。有必要进一步研究PMBE在氧化应激增强的情况下（如骨关节炎、高血压、2型糖尿病或其他与生活方式相关的疾病）的抗氧化能力。
