Liubimov B I, Smol'nikova N M, Strekalova S N, Kurochkin I G, Mitrofanov V S
Farmakol Toksikol. 1979 Sep-Oct;42(5):464-7.
Chronic toxicity of the benzodiazepine series tranquilizer phenazepam (5 and 50 mg/kg) administered per os for 1.3 and 6 months was studied in experiments on white rats, guinea pigs and dogs. It has been shown during varying time of observation that the drug neither decreases weight gain in the animals nor adversly acts on the blood or produces local irritating action. Histopathological changes in some internal organs proved irreversible. Administered at varying periods of pregnancy, phenazepam at an oral dose of 100 mg/kg exerted no embryotoxic or teratogenic action.
在对白鼠、豚鼠和狗进行的实验中，研究了口服苯二氮䓬类镇静剂非那西泮（5毫克/千克和50毫克/千克）1.3个月和6个月的慢性毒性。在不同的观察时间内发现，该药物既不降低动物的体重增加，也不对血液产生不良作用或产生局部刺激作用。一些内脏器官的组织病理学变化被证明是不可逆的。在不同孕期给予口服剂量为100毫克/千克的非那西泮，未产生胚胎毒性或致畸作用。
