伴有Jak 2 V671F阳性原发性血小板增多症的Zap-70阳性慢性淋巴细胞白血病：一种常见的缺陷干细胞？
Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell?
作者信息
Tabaczewski Piotr, Nadesan Sushani, Lim Seah H
机构信息
Department of Internal Medicine, Texas Tech University Health Sciences Center, Amarillo, United States.
出版信息
Leuk Res. 2009 Jun;33(6):854-5. doi: 10.1016/j.leukres.2008.09.002. Epub 2008 Oct 11.
Abstract
Essential thrombocythemia (ET) co-existing with chronic lymphocytic leukemia (CLL) is extremely rare. We report two cases of ET with Jak 2 V617F in Zap-70+ CLL. ET is a myeloproliferative stem cell disease. Zap-70 expression in CLL correlates with non-mutated immunoglobulin genes. The occurrence of a less mature CLL in patients with a pluripotential stem cell disease raises the possibility that an initial "trigger hit" occurred in a pre-Jak 2 common early progenitor in these patients. Subsequent additional molecular events accumulated independently following myeloid and lymphoid differentiation, leading to the development of two diseases of likely identical origin but different lineages.
摘要
原发性血小板增多症（ET）与慢性淋巴细胞白血病（CLL）共存极为罕见。我们报告了两例Zap-70阳性的CLL合并Jak 2 V617F突变的ET病例。ET是一种骨髓增殖性干细胞疾病。CLL中Zap-70的表达与未突变的免疫球蛋白基因相关。在多能干细胞疾病患者中出现较不成熟的CLL，提示这些患者可能在Jak 2之前的共同早期祖细胞中发生了初始的“触发打击”。随后，在髓系和淋巴系分化后，额外的分子事件独立积累，导致了两种可能起源相同但谱系不同的疾病的发生。
相似文献
1
Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell?伴有Jak 2 V671F阳性原发性血小板增多症的Zap-70阳性慢性淋巴细胞白血病：一种常见的缺陷干细胞？
Leuk Res. 2009 Jun;33(6):854-5. doi: 10.1016/j.leukres.2008.09.002. Epub 2008 Oct 11.
2
Absence of the V617F JAK2 mutation in the lymphoid compartment in a patient with essential thrombocythemia and B-chronic lymphocytic leukemia and in two relatives with lymphoproliferative disorders.真性红细胞增多症和B细胞慢性淋巴细胞白血病患者以及两名患有淋巴增殖性疾病的亲属的淋巴组织中未检测到V617F JAK2突变。
Acta Haematol. 2009;122(1):46-9. doi: 10.1159/000243721. Epub 2009 Oct 7.
3
Co-occurrence of JAK2 V617F-mutated essential thrombocythemia and chronic lymphocytic leukemia harboring der(8;17)(q10;q10).JAK2 V617F 突变型原发性血小板增多症与携带 der(8;17)(q10;q10) 的慢性淋巴细胞白血病共存。
Cancer Rep (Hoboken). 2022 Oct;5(10):e1658. doi: 10.1002/cnr2.1658. Epub 2022 Jun 17.
4
Two cases of concurrent development of essential thrombocythemia with chronic lymphocytic leukemia, one related to clonal B-cell lymphocytosis, tested by array comparative genomic hybridization.两例原发性血小板增多症与慢性淋巴细胞白血病同时发生的病例，其中一例与克隆性B细胞淋巴细胞增多症相关，通过阵列比较基因组杂交进行检测。
Int J Hematol. 2015 Jun;101(6):612-9. doi: 10.1007/s12185-014-1713-9. Epub 2014 Dec 10.
5
JAK2 V617F positive essential thrombocythemia developing in a patient with CD5⁻ chronic lymphocytic leukemia.JAK2 V617F 阳性原发性血小板增多症在 CD5⁻ 慢性淋巴细胞白血病患者中发生。
Chin Med J (Engl). 2012 Jun;125(11):2076-9.
6
7
ZAP-70 staining in chronic lymphocytic leukemia.慢性淋巴细胞白血病中的ZAP-70染色
Curr Protoc Cytom. 2005 May;Chapter 6:Unit 6.19. doi: 10.1002/0471142956.cy0619s32.
8
Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling.吉非替尼靶向表达ZAP-70的慢性淋巴细胞白血病细胞并抑制B细胞受体信号传导。
Cell Death Dis. 2014 Oct 2;5(10):e1439. doi: 10.1038/cddis.2014.391.
9
Quantification of ZAP-70 mRNA by real-time PCR is a prognostic factor in chronic lymphocytic leukemia.实时 PCR 检测 ZAP-70 mRNA 的表达水平是慢性淋巴细胞白血病的一个预后因素。
J Cancer Res Clin Oncol. 2012 Jun;138(6):1011-7. doi: 10.1007/s00432-012-1177-3. Epub 2012 Feb 24.
10
Chronic lymphocytic leukemia and myeloproliferative neoplasms concurrently diagnosed: clinical and biological characteristics.同时诊断的慢性淋巴细胞白血病和骨髓增殖性肿瘤：临床和生物学特征
Leuk Lymphoma. 2016 May;57(5):1054-9. doi: 10.3109/10428194.2015.1092527. Epub 2015 Oct 19.
引用本文的文献
1
Does Double Mean Trouble? Coexistence of Myeloproliferative and Lymphoproliferative Neoplasms.双重意味着麻烦吗？骨髓增殖性和淋巴细胞增殖性肿瘤的共存。
J Clin Med. 2024 Mar 21;13(6):1816. doi: 10.3390/jcm13061816.
2
Lymphoproliferative and Subsequent Myeloproliferative Disorder - A One Way Street?淋巴增殖性疾病及后续的骨髓增殖性疾病——一条单行道？
Balkan Med J. 2021 May;38(3):201-202. doi: 10.5152/balkanmedj.2021.21010.
3
Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience.髓系和淋系肿瘤的共存：单中心经验
Adv Hematol. 2019 Nov 3;2019:1486476. doi: 10.1155/2019/1486476. eCollection 2019.
4
Expression of CD markers in JAK2 positive myeloproliferative neoplasms: Prognostic significance.JAK2 阳性骨髓增殖性肿瘤中 CD 标志物的表达：预后意义。
Oncol Rev. 2018 Oct 2;12(2):373. doi: 10.4081/oncol.2018.373. eCollection 2018 Jul 4.
5
Concomitant myeloproliferative and lymphoproliferative neoplasms, distinct progenitors: A case report and review of the literature.伴有骨髓增殖性和淋巴增殖性肿瘤，不同的祖细胞：一例病例报告及文献复习
Mol Clin Oncol. 2018 Sep;9(3):347-349. doi: 10.3892/mco.2018.1682. Epub 2018 Jul 19.
6
Two cases of concurrent development of essential thrombocythemia with chronic lymphocytic leukemia, one related to clonal B-cell lymphocytosis, tested by array comparative genomic hybridization.两例原发性血小板增多症与慢性淋巴细胞白血病同时发生的病例，其中一例与克隆性B细胞淋巴细胞增多症相关，通过阵列比较基因组杂交进行检测。
Int J Hematol. 2015 Jun;101(6):612-9. doi: 10.1007/s12185-014-1713-9. Epub 2014 Dec 10.
7
Concomitant Myeloproliferative and Lymphoid Neoplasms in Two Patients Positive for JAK2 V617F Mutation. Case Report and Literature Review.两名JAK2 V617F突变阳性患者的伴发骨髓增殖性和淋巴样肿瘤。病例报告及文献综述
Indian J Hematol Blood Transfus. 2014 Sep;30(Suppl 1):120-3. doi: 10.1007/s12288-013-0281-0. Epub 2013 Jun 14.
8
Coexistence of chronic lymphocytic leukemia and myeloproliferative neoplasm.慢性淋巴细胞白血病与骨髓增殖性肿瘤共存。
Case Rep Oncol Med. 2014;2014:512928. doi: 10.1155/2014/512928. Epub 2014 Sep 2.
9
Simultaneous presentation of JAK2 V617F mutation-related essential thrombocythemia and B-cell chronic lymphocytic leukemia.JAK2 V617F突变相关的原发性血小板增多症与B细胞慢性淋巴细胞白血病同时出现。
Blood Res. 2014 Jun;49(2):134-7. doi: 10.5045/br.2014.49.2.134. Epub 2014 Jun 25.
10
JAK2 V617F detected in two B-cell chronic lymphocytic leukemia patients without coexisting Philadelphia chromosome-negative myeloproliferative neoplasms: A report of two cases.在两名无合并费城染色体阴性骨髓增殖性肿瘤的B细胞慢性淋巴细胞白血病患者中检测到JAK2 V617F：两例报告。
Oncol Lett. 2014 Aug;8(2):841-844. doi: 10.3892/ol.2014.2168. Epub 2014 May 22.
本文引用的文献
1
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders.JAK2在骨髓增殖性疾病发病机制及治疗中的作用。
Nat Rev Cancer. 2007 Sep;7(9):673-83. doi: 10.1038/nrc2210.
2
Association of essential thrombocythemia and chronic lymphocytic leukemia: absence of the V617F JAK2 mutation in the lymphoid compartment.原发性血小板增多症与慢性淋巴细胞白血病的关联：淋巴组织中不存在V617F JAK2突变
Am J Hematol. 2007 Jun;82(6):500-1. doi: 10.1002/ajh.20870.
3
Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation.骨髓增殖性疾病中JAK2的突变：时机、克隆性研究、细胞遗传学关联及在白血病转化中的作用。
Blood. 2006 Nov 15;108(10):3548-55. doi: 10.1182/blood-2005-12-013748. Epub 2006 Jul 27.
4
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.一种导致持续性信号传导的独特克隆性JAK2突变会引发真性红细胞增多症。
Nature. 2005 Apr 28;434(7037):1144-8. doi: 10.1038/nature03546.
5
Coexistence of chronic lymphocytic leukemia and essential thrombocythemia.
Leuk Lymphoma. 2003 Aug;44(8):1425-31. doi: 10.1080/1042819031000097348.
6
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile.ZAP-70表达可识别出一种慢性淋巴细胞白血病亚型，其免疫球蛋白基因未发生突变，临床预后较差，且具有独特的基因表达谱。
Blood. 2003 Jun 15;101(12):4944-51. doi: 10.1182/blood-2002-10-3306. Epub 2003 Feb 20.
7
Chronic lymphocytic leukaemia in a patient with essential thrombocythaemia.
Clin Lab Haematol. 1998 Dec;20(6):377-9. doi: 10.1046/j.1365-2257.1998.00170.x.
8
[Simultaneous presentation of chronic lymphocytic leukosis and essential thrombocythemia].
An Med Interna. 1995 Nov;12(11):566.
9
Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia.B淋巴细胞参与真性红细胞增多症和原发性血小板增多症的证据。
J Clin Invest. 1985 Apr;75(4):1388-90. doi: 10.1172/JCI111840.
10
Coexistence of essential thrombocythemia and chronic lymphocytic leukemia.原发性血小板增多症与慢性淋巴细胞白血病并存。
Acta Haematol. 1991;85(1):31-3. doi: 10.1159/000204848.
Zotero 插件