Laskowski-Arce Michelle A, Orth Kim
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Appl Environ Microbiol. 2008 Dec;74(23):7183-8. doi: 10.1128/AEM.01332-08. Epub 2008 Oct 10.
Vibrio parahaemolyticus is a food-borne pathogen that naturally inhabits both marine and estuarine environments. Free-living protozoa exist in similar aquatic environments and function to control bacterial numbers by grazing on free-living bacteria. Protozoa also play an important role in the survival and spread of some pathogenic species of bacteria. We investigated the interaction between the protozoan Acanthamoeba castellanii and the bacterium Vibrio parahaemolyticus. We found that Acanthamoeba castellanii does not prey on Vibrio parahaemolyticus but instead secretes a factor that promotes the survival of Vibrio parahaemolyticus in coculture. These studies suggest that protozoa may provide a survival advantage to an extracellular pathogen in the environment.
副溶血性弧菌是一种食源性病原体,自然栖息于海洋和河口环境。自由生活的原生动物存在于类似的水生环境中,通过捕食自由生活的细菌来控制细菌数量。原生动物在某些致病细菌物种的生存和传播中也起着重要作用。我们研究了原生动物卡氏棘阿米巴与副溶血性弧菌之间的相互作用。我们发现卡氏棘阿米巴并不捕食副溶血性弧菌,而是分泌一种因子,该因子能促进副溶血性弧菌在共培养中的存活。这些研究表明,原生动物可能为环境中的细胞外病原体提供生存优势。