微环境在肿瘤血管生成中的作用。
The role of microenvironment in tumor angiogenesis.
机构信息
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, 70124, Bari, Italy,
出版信息
Genes Nutr. 2008 Apr;3(1):29-34. doi: 10.1007/s12263-008-0076-3.
Abstract
Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in tumors and in multiple myeloma. The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed.
摘要
肿瘤微环境通过提供生存信号、分泌生长和促血管生成因子以及直接黏附分子相互作用，对肿瘤细胞的增殖、血管生成、侵袭和转移至关重要。本文探讨了其在肿瘤和多发性骨髓瘤中诱导血管生成反应中的重要性。还讨论了通过靶向肿瘤微环境治疗肿瘤的临床前和临床试验的令人鼓舞的结果。
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