肺发育假腺期间充质细胞的凋亡影响分支形态发生。
Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis.
作者信息
Wongtrakool Cherry, Roman Jesse
机构信息
Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
出版信息
Exp Lung Res. 2008 Oct;34(8):481-99. doi: 10.1080/01902140802271842.
Abstract
Apoptosis has been implicated as an important process in the development of several organ systems, including limbs, kidneys, and the heart. In developing murine lungs, the authors found that apoptosis was more predominant during the pseudoglandular stage of lung development than during the saccular stage, with 93% of the apoptotic structures in the mesenchyme. Murine lung explants cultured in the presence of zinc chloride and aurintricarboxylic acid, 2 blockers of endonuclease function, showed decreased branching. These observations suggest that apoptosis predominates in mesenchymal cells during the pseudoglandular stage of lung development, and may be important for normal progression of lung branching morphogenesis.
摘要
细胞凋亡已被认为是包括四肢、肾脏和心脏在内的多个器官系统发育过程中的一个重要过程。在发育中的小鼠肺中，作者发现细胞凋亡在肺发育的假腺泡期比在囊状期更为显著，间充质中有93%的凋亡结构。在氯化锌和金精三羧酸（两种核酸内切酶功能阻滞剂）存在的情况下培养的小鼠肺外植体显示出分支减少。这些观察结果表明，在肺发育的假腺泡期，细胞凋亡在间充质细胞中占主导地位，并且可能对肺分支形态发生的正常进展很重要。
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