Haugen G, Bjøro K, Stray-Pedersen S
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Gynecol Obstet Invest. 1991;31(4):208-12. doi: 10.1159/000293160.
The effect of serotonin, PGE2 and PGF2 alpha on the vascular tension in human umbilical arteries has been investigated during in vitro perfusions. All autacoids induced dose-dependent biphasic pressure responses when added to the perfusate. When added to the extraumbilical fluid, serotonin induced monophasic vasoconstrictory responses, whereas PGE2 and PGF2 alpha did not elicit significant changes except for minor pressure oscillations in some experiments. The results obtained suggest a contributory role of the endothelial layer in the action of these autacoids on the smooth muscle tension.
在体外灌注过程中，研究了血清素、前列腺素E2（PGE2）和前列腺素F2α（PGF2α）对人脐动脉血管张力的影响。当将所有自分泌物质添加到灌注液中时，均诱导出剂量依赖性双相压力反应。当添加到脐外液中时，血清素诱导单相血管收缩反应，而PGE2和PGF2α除了在某些实验中引起轻微压力振荡外，未引起显著变化。所得结果表明，内皮细胞层在这些自分泌物质对平滑肌张力的作用中起作用。
