González C, Cruz M A, Gallardo V, Albornoz J, Bravo I
Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Gynecol Obstet Invest. 1993;35(2):86-90. doi: 10.1159/000292671.
In vitro experiments using isolated rings and perfused segments of human chorionic veins, were designed to determine the effects of serotonin and their interaction with PGF2 alpha on vascular tension and perfusion pressure. These vessels responded vigorously with high sensitivity to the vasoconstrictor effects of serotonin in both experimental designs. Administration of PGF2 alpha also led to constriction of the veins, but this autacoid is at least 100 times less potent than serotonin. When adding PGF2 alpha previously to serotonin to the bathing fluid or to the perfusate, the serotonin response was significantly potentiated, increasing the maximal contractile response in 116 +/- 12% and the perfusion pressure in 180 +/- 25%. Both autacoids probably operate in this vascular bed interacting with each other and playing an important role in the regulation of placental blood flow in vivo.
使用人绒毛膜静脉的离体血管环和灌注节段进行的体外实验，旨在确定5-羟色胺的作用及其与前列腺素F2α对血管张力和灌注压力的相互作用。在这两种实验设计中，这些血管对5-羟色胺的血管收缩作用反应强烈且敏感性高。给予前列腺素F2α也会导致静脉收缩，但这种自体活性物质的效力至少比5-羟色胺低100倍。当预先将前列腺素F2α添加到5-羟色胺的浴液或灌注液中时，5-羟色胺反应明显增强，最大收缩反应增加116±12%，灌注压力增加180±25%。这两种自体活性物质可能在该血管床中相互作用，并在体内胎盘血流调节中发挥重要作用。
