Haugen G, Bjøro K, Stray-Pedersen S
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Scand J Clin Lab Invest. 1991 Apr;51(2):131-5. doi: 10.3109/00365519109091098.
The influence of extra-umbilical applications of serotonin and prostaglandins PGE2 and PGF2 alpha on the endogenous production of prostacyclin and thromboxane in human umbilical arteries was registered during in vitro perfusion by use of specific radio-immunoassays. PGE2 and PGF2 alpha caused significant dose-dependent increases in the production of prostacyclin, but no specific alterations in that of thromboxane. Serotonin did not lead to any changes in the prostanoid formation. The results provide indirect support for the assumption that prostanoids synthesized in the vessel wall, predominantly in the endothelial cells, serve as mediators in the action of autacoids on vascular smooth muscle tension.
通过使用特定的放射免疫测定法，在体外灌注过程中记录了血清素以及前列腺素PGE2和PGF2α在脐外应用对人脐动脉中前列环素和血栓素内源性产生的影响。PGE2和PGF2α导致前列环素产生显著的剂量依赖性增加，但血栓素的产生没有特定变化。血清素未导致类前列腺素形成发生任何变化。这些结果为以下假设提供了间接支持：血管壁（主要是内皮细胞）中合成的类前列腺素作为自分泌物质对血管平滑肌张力作用的介质。
