Klempel K
Psychiatrisches Krankenhaus, Marburg.
Fortschr Neurol Psychiatr. 1991 Jun;59(6):239-46. doi: 10.1055/s-2007-1000700.
Two collectives of chronic schizophrenics were psychometrically rated by means of the BPRS and of Gebhardt's primary AMP-scales. Their scores of coexistent Positive and Negative Symptomatology were correlated with equivalents of catecholergic levels of tone as represented by plasma tyrosine concentration in its role as the catecholergic precursor. Levels of catecholergic tone state- and time-dependently correlated directly with Positive and inversely with Negative Symptomatology. Opposite ends of catecholergic tone from supra- to subnormal ranges ran parallel to a psychometric continuum from predominant Positive to predominant Negative Symptomatology, to a diagnostic continuum from "paranoid" to "disorganised/hebephrenic", and to a global metabolic continuum from under- to overweight. Findings did not support the hypothesis on psychotogenic dopaminergic supersensitivity. Postulated was a primary psychotogenic process of denervation or/and degeneration of a specific 'trigger system', and supersensitivity-induced neuronal damage was conjectured the biological substrate of Negative Symptomatology. A pathophysiological hypothesis put forth, corresponded with Cannon's Rules within the frame of functional neuronal plasticity.
通过简明精神病评定量表（BPRS）和格布哈特的主要AMP量表，对两组慢性精神分裂症患者进行了心理测量评分。他们共存的阳性和阴性症状学得分与儿茶酚胺能张力水平的等效值相关，血浆酪氨酸浓度作为儿茶酚胺能前体发挥作用，代表了儿茶酚胺能张力水平。儿茶酚胺能张力水平在状态和时间上与阳性症状直接相关，与阴性症状呈负相关。儿茶酚胺能张力从超正常范围到低于正常范围的两端，与从主要阳性症状到主要阴性症状的心理测量连续体、从“偏执型”到“紊乱/青春型”的诊断连续体以及从体重过轻到超重的整体代谢连续体平行。研究结果不支持精神源性多巴胺能超敏反应的假说。推测存在一个特定“触发系统”的去神经支配或/和退化的原发性精神源性过程，超敏反应诱导的神经元损伤被推测为阴性症状学的生物学基础。提出的病理生理假说与功能神经元可塑性框架内的坎农法则相符。
