使用粒细胞巨噬细胞集落刺激因子基因敲除小鼠在结核病复发模型中对实验性化合物进行测试。
Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.
作者信息
Woolhiser Lisa K, Hoff Donald R, Marietta Karen S, Orme Ian M, Lenaerts Anne J
机构信息
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
Antimicrob Agents Chemother. 2009 Jan;53(1):306-8. doi: 10.1128/AAC.01346-07. Epub 2008 Oct 13.
Abstract
This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.
摘要
本研究描述了一种用于评估化合物对持续存在的结核分枝杆菌杀菌活性的体内模型。在粒细胞-巨噬细胞集落刺激因子基因敲除小鼠中，先用异烟肼和利福平进行初始治疗，在3周内可使细菌数量减少99%以上。随后用单一药物进行治疗，以评估其对1%残留杆菌的活性以及疾病复发情况。
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