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本文引用的文献

1
Salmonella enterica serotype Typhimurium carrying hybrid virulence-resistance plasmids (pUO-StVR): a new multidrug-resistant group endemic in Spain.携带杂交毒力-抗性质粒（pUO-StVR）的肠炎沙门氏菌鼠伤寒血清型：西班牙一种新的多药耐药地方性菌群。
Int J Med Microbiol. 2008 Apr;298(3-4):253-61. doi: 10.1016/j.ijmm.2007.04.008. Epub 2007 Jun 26.
2
[Outbreak of gastroenteritis in a nursery school caused by a strain of Salmonella enterica serovar Typhimurium carrying the hybrid virulence-resistance plasmid pUO-StVR2].[携带杂交毒力-耐药质粒pUO-StVR2的鼠伤寒沙门氏菌菌株引起的幼儿园胃肠炎暴发]
Enferm Infecc Microbiol Clin. 2007 Jun-Jul;25(6):376-81. doi: 10.1157/13106962.
3
Complete nucleotide sequences of 84.5- and 3.2-kb plasmids in the multi-antibiotic resistant Salmonella enterica serovar Typhimurium U302 strain G8430.多重耐药性肠炎沙门氏菌鼠伤寒血清型U302菌株G8430中84.5kb和3.2kb质粒的完整核苷酸序列。
Plasmid. 2007 Jan;57(1):29-43. doi: 10.1016/j.plasmid.2006.05.005. Epub 2006 Jul 7.
4
OXA-1 is OXA-30 is OXA-1.OXA - 1等同于OXA - 30等同于OXA - 1 。
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5
Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.鉴定大肠杆菌尿路致病菌株中受到正选择的基因：一种比较基因组学方法。
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5977-82. doi: 10.1073/pnas.0600938103. Epub 2006 Apr 3.
6
Distribution and function of plasmids in Salmonella enterica.肠炎沙门氏菌中质粒的分布与功能
Vet Microbiol. 2006 Jan 10;112(1):1-10. doi: 10.1016/j.vetmic.2005.10.030. Epub 2005 Nov 21.
7
Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUO-StVR2.携带毒力抗性质粒pUO-StVR2的新兴多重耐药性肠炎沙门氏菌鼠伤寒血清型菌株的分子流行病学
J Antimicrob Chemother. 2006 Jan;57(1):39-45. doi: 10.1093/jac/dki400. Epub 2005 Nov 12.
8
Prokaryotic toxin-antitoxin stress response loci.原核生物毒素-抗毒素应激反应基因座。
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9
The 120 592 bp IncF plasmid pRSB107 isolated from a sewage-treatment plant encodes nine different antibiotic-resistance determinants, two iron-acquisition systems and other putative virulence-associated functions.从一家污水处理厂分离出的120592碱基对的IncF质粒pRSB107编码九种不同的抗生素抗性决定簇、两种铁获取系统以及其他假定的毒力相关功能。
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10
Towards more virulent and antibiotic-resistant Salmonella?会出现更具毒性和抗药性的沙门氏菌吗？
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pUO-StVR2的特性分析，pUO-StVR2是一种从鼠伤寒沙门氏菌血清型鼠伤寒的pSLT毒力质粒进化而来的毒力抗性质粒。

Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium.

作者信息

Herrero Ana, Mendoza M Carmen, Rodicio Rosaura, Rodicio M Rosario

机构信息

Departamento de Biología Funcional (Area de Microbiología) and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.

出版信息

Antimicrob Agents Chemother. 2008 Dec;52(12):4514-7. doi: 10.1128/AAC.00563-08. Epub 2008 Oct 13.

DOI:10.1128/AAC.00563-08
PMID:18852276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2592850/
Abstract

pUO-StVR2 is a virulence-resistance plasmid which originated from pSLT of Salmonella enterica serovar Typhimurium through acquisition of a complex resistance island, flanked by regions that provide a toxin-antitoxin system and an iron uptake system. The presence of resistance and virulence determinants on the same plasmid allows coselection of both properties, potentially increasing health risks.

摘要

pUO-StVR2是一种毒力抗性质粒，它起源于鼠伤寒沙门氏菌的pSLT，通过获得一个复杂的抗性岛，该抗性岛两侧是提供毒素-抗毒素系统和铁摄取系统的区域。同一质粒上存在抗性和毒力决定因素使得这两种特性能够共同选择，可能增加健康风险。