口服米替福新与胃肠外N-甲基葡糖胺锑酸盐治疗亚马逊利什曼原虫（利什曼原虫属）引起的实验性利什曼病的比较研究
[Comparative study between oral miltefosine and parenteral N-metil glucamine antimoniate for the treatment of experimental leishmaniasis caused Leishmania (Leishmania) amazonensis].
作者信息
Costa Filho Arnoldo Velloso da, Lucas Iris Campos, Sampaio Raimunda Nonata Ribeiro
机构信息
Laboratório de Dermatomicologia, Universidade de Brasília, Brasília, DF.
出版信息
Rev Soc Bras Med Trop. 2008 Jul-Aug;41(4):424-7. doi: 10.1590/s0037-86822008000400022.
UNLABELLED
Twenty-five mice were infected with Leishmania amazonensis and treated with glucamine and oral miltefosine. The criteria used were pad measurements and investigations of amastigotes and cultures after treatment.
MEASUREMENTS
miltefosine 2.43 mm and glucamine 3.46 mm (p: 0.05). Miltefosine smears and cultures were negative. Glucamine produced two positive smears and the cultures were positive (p < 0.05). Miltefosine was similar to or better than glucamine.
未标记
25只小鼠感染亚马逊利什曼原虫后，用葡糖胺和口服米替福新进行治疗。所采用的标准为治疗后对爪垫的测量以及对无鞭毛体和培养物的研究。
测量结果
米替福新为2.43毫米，葡糖胺为3.46毫米（p值：0.05）。米替福新涂片和培养物均为阴性。葡糖胺产生了两份阳性涂片，培养物也呈阳性（p < 0.05）。米替福新与葡糖胺效果相当或更佳。
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