Peterson Jennifer M, Guttridge Denis C
Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 23210, USA.
Int Rev Immunol. 2008;27(5):375-87. doi: 10.1080/08830180802302389.
Signaling through nuclear factor-kappa B (NF-kappaB) is emerging as an important regulator of muscle development, maintenance, and regeneration. Classic signaling modulates early muscle development by enhancing proliferation and inhibiting differentiation, and alternative signaling promotes myofiber maintenance and metabolism. Likewise, NF-kappaB signaling is critical for the development of immunity. Although these processes occur normally, dysregulation of NF-kappaB signaling has prohibitive effects on muscle growth and regeneration and can perpetuate inflammation in muscle diseases. Aberrant NF-kappaB signaling from immune and muscle cells has been detected and implicated in the pathologic progression of numerous dystrophies and myopathies, indicating that targeted NF-kappaB inhibitors may prove clinically beneficial.
通过核因子-κB（NF-κB）的信号传导正逐渐成为肌肉发育、维持和再生的重要调节因子。经典信号传导通过增强增殖和抑制分化来调节早期肌肉发育，而选择性信号传导则促进肌纤维的维持和代谢。同样，NF-κB信号传导对免疫发育至关重要。尽管这些过程正常发生，但NF-κB信号传导的失调对肌肉生长和再生具有抑制作用，并可使肌肉疾病中的炎症持续存在。已检测到免疫细胞和肌肉细胞中异常的NF-κB信号传导，并认为其与多种营养不良和肌病的病理进展有关，这表明靶向NF-κB抑制剂可能具有临床益处。
