Verma Nitin, Lazarchick John, Gudena Vinay, Turner Jeffrey, Chaudhary Uzair B
Department of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Am J Med Sci. 2008 Oct;336(4):336-41. doi: 10.1097/MAJ.0b013e31817242bc.
Testicular lymphoma is a lethal disease with a median survival of approximately 12 to 24 months. It is the most common testicular malignancy in men older than 60 years of age. Testicular lymphoma has a predilection for widespread dissemination to unusual sites, including the central nervous system, contralateral testis, Waldeyer's ring, skin, and lung. Doxorubicin based chemotherapy with prophylactic intrathecal chemotherapy and radiation to the contralateral testis seems most promising. This review article will focus on the presentation, pathology, patterns of relapse and challenges in improving the outcome of this disease.
睾丸淋巴瘤是一种致命疾病，中位生存期约为12至24个月。它是60岁以上男性中最常见的睾丸恶性肿瘤。睾丸淋巴瘤易于广泛播散至不常见部位，包括中枢神经系统、对侧睾丸、咽淋巴环、皮肤和肺部。基于多柔比星的化疗联合预防性鞘内化疗以及对侧睾丸放疗似乎最有前景。这篇综述文章将聚焦于该病的临床表现、病理学、复发模式以及改善其治疗结果所面临的挑战。
