Misra G C, Samal A K, Bose S L
SCB Medical College, Cuttack.
J Assoc Physicians India. 1991 Feb;39(2):182-4.
Thirteen patients of duodenal ulcer, below 20 years of age, ten age and sex matched controls and 17 first probands were studied to find out (i) the special characteristics of this duodenal ulcer subtype and (ii) the serum alpha-1-antitrypsin (alpha-1-AT) activity in these patients and their first probands. Basal and maximal acid output, and serum level of alpha-1-AT were measured, and serum agar gel electrophoresis done, in the above subjects. Special characteristics like positive family history, and high basal (p less than or equal to 0.01) and maximal (p less than or equal to 0.001) acid output were noted in these patients. Serum alpha-1-AT was found to be deficient in nine patients. Five first probands also had the heterozygous level of the enzyme deficiency. Thus, patients of early onset duodenal ulcer seem to have special characteristics with alpha-1-antitrypsin deficiency in them as well as in their first probands.
对13名年龄在20岁以下的十二指肠溃疡患者、10名年龄和性别匹配的对照者以及17名一级先证者进行了研究，以查明（i）这种十二指肠溃疡亚型的特殊特征，以及（ii）这些患者及其一级先证者的血清α-1-抗胰蛋白酶（α-1-AT）活性。对上述受试者测量了基础胃酸分泌量和最大胃酸分泌量以及α-1-AT的血清水平，并进行了血清琼脂凝胶电泳。在这些患者中发现了诸如阳性家族史以及高基础胃酸分泌量（p≤0.01）和最大胃酸分泌量（p≤0.001）等特殊特征。发现9名患者血清α-1-AT缺乏。5名一级先证者也具有杂合水平的酶缺乏。因此，早发性十二指肠溃疡患者似乎具有特殊特征，他们自身以及其一级先证者都存在α-1-抗胰蛋白酶缺乏。
