Biemond I, Goedhard J G, Klasen E C, van den Boomgaard D M, Kreuning J, Peña A S, Lamers C B
Department of Gastroenterology and Hepatology, Leiden University Hospital, The Netherlands.
Digestion. 1988;39(1):20-5. doi: 10.1159/000199603.
Hereditary alpha 1-antitrypsin (alpha 1-AT) deficiency has been suggested to be associated with peptic ulcer disease. Since the serum concentration of the enzyme is the result of both hereditary and nonhereditary factors, we have studied not only the serum levels but also the alpha 1-AT electrophoretic variants in 177 Dutch patients with duodenal ulcer disease and compared with 357 healthy blood donors. No relation was found between any of the alpha 1-antitrypsin phenotypes and duodenal ulcer disease. Serum levels of alpha 1-AT were significantly higher than in the controls in the patients. This study does not support an association between hereditary alpha 1-AT deficiency and duodenal ulcer disease, and makes therefore a possible role of such a deficiency in the etiology of peptic ulcer disease highly unlikely.
遗传性α1 -抗胰蛋白酶（α1 - AT）缺乏症被认为与消化性溃疡病有关。由于该酶的血清浓度是遗传和非遗传因素共同作用的结果，我们不仅研究了177例荷兰十二指肠溃疡病患者的血清水平，还研究了其α1 - AT电泳变体，并与357名健康献血者进行了比较。未发现任何α1 -抗胰蛋白酶表型与十二指肠溃疡病之间存在关联。患者的α1 - AT血清水平显著高于对照组。本研究不支持遗传性α1 - AT缺乏症与十二指肠溃疡病之间存在关联，因此这种缺乏症在消化性溃疡病病因学中发挥作用的可能性极小。
