Ali M M, Habibullah C M
Department of Gastroenterology, Osmania General Hospital, Hyderabad, India.
Neth J Med. 1990 Oct;37(3-4):145-8.
An alpha-1-antitrypsin study was carried out on 184 patients with endoscopically proven duodenal ulcer, 66 first degree relatives of the patients and in 150 healthy controls, to establish the role of genetic factors in the etiology of duodenal ulcer. Alpha-1-antitrypsin served as a genetic marker in this study; it was estimated in terms of serum trypsin inhibitor capacity by the method of Jaccobson. Deficiency of alpha-1-antitrypsin level was recorded in patients as well as their family members when compared with controls.
对184例经内镜证实为十二指肠溃疡的患者、66例患者的一级亲属以及150名健康对照者进行了α1抗胰蛋白酶研究，以确定遗传因素在十二指肠溃疡病因中的作用。在本研究中，α1抗胰蛋白酶作为一种遗传标记；采用雅各布森方法根据血清胰蛋白酶抑制能力对其进行评估。与对照组相比，患者及其家庭成员中均记录到α1抗胰蛋白酶水平缺乏。
