Kiryluk Krzysztof
Columbia University, Department of Medicine, Division of Nephrology, New York, New York 10033, USA.
Kidney Int. 2008 Nov;74(9):1109-12. doi: 10.1038/ki.2008.479.
The linkage approach to quantitative traits, such as estimated glomerular filtration rate (eGFR), has been utilized in several recent studies aimed at identification of susceptibility loci. However, the heterogeneity and complex architecture of the eGFR phenotype make the gene mapping efforts inherently difficult. Mottl and colleagues attempt to tackle this problem in their analysis of a unique family-based cohort of American Indians.
定量性状的连锁分析方法，如估计肾小球滤过率（eGFR），已在最近几项旨在识别易感基因座的研究中得到应用。然而，eGFR表型的异质性和复杂结构使得基因定位工作本身就很困难。莫特尔及其同事在对一个独特的美洲印第安人家庭队列进行分析时试图解决这个问题。
