Kørner Alex, Lopez Ana G, Lauritzen Lise, Andersen Per K, Kessing Lars V
Psychogeriatric Unit, Psychiatric Hospital, Hilleroed, Denmark.
Aging Ment Health. 2008 Sep;12(5):625-9. doi: 10.1080/13607860802343118.
To examine whether very late first-contact delusional disorder carries a risk for later development of dementia.
By linkage of the psychiatric and the somatic nationwide registers of all out- and in-patients with hospital contact in Denmark, we included all 60+ patients with first ever from 1 January 1994 to 31 December 2001 with the index main diagnosis: delusional disorder. First contact osteoarthritis patients as well as the general population were used as controls. A total of 1,437 patients with persistent delusional disorder and 7,302 patients with osteoarthritis were included. Median follow-up time until first diagnosis of dementia at discharge was 1.87 and 4.40 years, respectively. The probability of getting a dementia diagnosis was estimated using Poisson regression models with dementia as the outcome of interest.
Patients with very late first-contact delusional disorder had an 8.14 (95% CI, 6.51; 10.19) times increased rate of subsequently developing dementia compared with very late first contact osteoarthritis patients. Compared with the general population the rate ratio was 5.49 (95% CI, 4.81; 6.26).
Very late first-contact delusional disorder increases the risk of subsequently getting a diagnosis of dementia 5-8 times compared with osteoarthritis patients and the general population.
研究极晚首次接触妄想性障碍患者日后患痴呆症的风险。
通过丹麦全国范围内所有住院和门诊患者的精神病学和躯体疾病登记系统的关联，我们纳入了1994年1月1日至2001年12月31日期间所有60岁及以上首次以妄想性障碍作为主要诊断指标的患者。首次接触骨关节炎患者以及普通人群作为对照。共纳入1437例持续性妄想性障碍患者和7302例骨关节炎患者。直至出院时首次诊断为痴呆症的中位随访时间分别为1.87年和4.40年。使用以痴呆症为感兴趣结局的泊松回归模型估计患痴呆症诊断的概率。
与极晚首次接触骨关节炎患者相比，极晚首次接触妄想性障碍患者随后患痴呆症的发生率增加了8.14倍（95%可信区间，6.51；10.19）。与普通人群相比，发病率比值为5.49（95%可信区间，4.81；6.26）。
与骨关节炎患者和普通人群相比，极晚首次接触妄想性障碍患者随后被诊断为痴呆症的风险增加了5至8倍。
