Seeber S J, White J L, Hem S L
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiania.
J Parenter Sci Technol. 1991 May-Jun;45(3):156-9.
The solubilization of three commercially available aluminum-containing adjuvants by citrate anion was studied. Amorphous aluminum hydroxyphosphate and boehmite were both solubilized, however, amorphous aluminum hydroxyphosphate dissolved significantly faster than boehmite. The results suggest that citrate and other alpha-hydroxy carboxylate anions in the interstitial fluid are able to solubilize and thereby facilitate the excretion of aluminum from aluminum-containing adjuvants which are administered by intramuscular injection. The results also suggest that the release of antigen following administration may be significantly more rapid from an amorphous aluminum hydroxyphosphate-adjuvanted vaccine in comparison to a boehmite-adjuvanted vaccine.
研究了柠檬酸根阴离子对三种市售含铝佐剂的增溶作用。无定形羟基磷酸铝和勃姆石均被增溶，然而，无定形羟基磷酸铝的溶解速度明显快于勃姆石。结果表明，组织液中的柠檬酸根和其他α-羟基羧酸根阴离子能够增溶含铝佐剂中的铝，从而促进其经肌肉注射给药后的排泄。结果还表明，与勃姆石佐剂疫苗相比，无定形羟基磷酸铝佐剂疫苗给药后抗原的释放可能明显更快。
