Cabane J, Raphaël M, Lamas G, Mossalayi D, Dubois A, Chomette G, Godeau P, Marty-Double C, Rossi J F
Department of Internal Medicine, Saint-Antoine Hospital, Paris, France.
Laryngoscope. 1991 Sep;101(9):998-1001. doi: 10.1288/00005537-199109000-00012.
Malignant centrofacial granuloma (MCFG) is a clinical entity characterized by a relentless ulceration of the upper airway involving the nose, palate, and face, without any demonstrable etiology. The origin of 11 cases were analyzed with the help of cell-surface immunostaining in all and with T-cell receptor gene (TCR) rearrangement in 3. The results show that most of the cases of MCFG are in fact T-cell lymphomas with cell-surface antigens (CD2, CD7, CD3) consistent with either early or mature T lymphocytes. However, some cases exhibit B-lymphoid (CD19, CD20) or histiomonocytic (CD13, CD14) lineage-specific markers. In conclusion, despite its remarkable clinical unity, MCFG is a heterogeneous group of neoplastic diseases, most but not all of which may be classified as T-cell lymphoma.
恶性面中部肉芽肿（MCFG）是一种临床病症，其特征为上呼吸道包括鼻、腭和面部出现持续性溃疡，且无任何可证实的病因。对11例病例的起源进行了分析，全部病例均借助细胞表面免疫染色进行分析，3例还进行了T细胞受体基因（TCR）重排分析。结果显示，大多数MCFG病例实际上是T细胞淋巴瘤，其细胞表面抗原（CD2、CD7、CD3）与早期或成熟T淋巴细胞一致。然而，一些病例表现出B淋巴细胞（CD19、CD20）或组织细胞单核细胞（CD13、CD14）谱系特异性标志物。总之，尽管MCFG在临床上具有显著的一致性，但它是一组异质性肿瘤疾病，其中大多数（但并非全部）可归类为T细胞淋巴瘤。
