Abramovitz J N, Neff S R
Department of Neurosurgery, New England Medical Center, Boston, Massachusetts.
Neurosurgery. 1991 Aug;29(2):301-7; discussion 307-8.
The Prospective Lumbar Discectomy Study enrolled 740 patients in a multiphysician, multicenter, consecutive patient protocol to evaluate the indications and efficacy of lumbar discectomy. Five hundred and thirteen patients could be evaluated at 3 months after surgery. Stepwise logistic regression showed that the factors of fraction of pain referred to the back, work-related injury, absence of back pain on straight leg-raise examination, correspondence of leg pain to typical radicular patterns, leg pain on straight leg-raise examination, and reflex asymmetry were independently predictive of good outcome from surgery. Univariate analysis of the case with different numbers of predictive factors present showed that use of the operating microscope, sensory deficit, central disc bulge, and free disc fragment were correlated with outcome only in subgroups. An analysis of unsatisfactory outcomes showed two patterns: one of failure as a result of mechanical back pain and one of failure as a result of radiculopathy. Factors predictive of outcome did not influence the type of failure. In a stepwise logistic regression analysis, facetectomy and preoperative sensory deficit were associated with increased likelihood of mechanical back pain failure, while preoperative motor deficit was associated with an increased likelihood of radicular failure. The results support several intuitively derived and commonly believed principles of lumbar disc surgery.
前瞻性腰椎间盘切除术研究采用多医生、多中心、连续患者方案,纳入740例患者,以评估腰椎间盘切除术的适应证和疗效。513例患者可在术后3个月进行评估。逐步逻辑回归分析显示,背部牵涉痛比例、工伤、直腿抬高检查时无背痛、腿痛与典型神经根模式相符、直腿抬高检查时腿痛以及反射不对称等因素可独立预测手术的良好预后。对存在不同数量预测因素的病例进行单因素分析显示,手术显微镜的使用、感觉障碍、中央椎间盘突出和游离椎间盘碎片仅在亚组中与预后相关。对不满意结果的分析显示出两种模式:一种是由于机械性背痛导致的手术失败,另一种是由于神经根病导致的手术失败。预测预后的因素并不影响失败的类型。在逐步逻辑回归分析中,小关节切除术和术前感觉障碍与机械性背痛导致手术失败的可能性增加相关,而术前运动障碍与神经根性手术失败的可能性增加相关。这些结果支持了一些凭直觉得出且普遍认可的腰椎间盘手术原则。