Alanen A, Komu M, Bondestam S, Toikkanen S
Department of Diagnostic Radiology, University Central Hospital, Turku, Finland.
Phys Med Biol. 1991 Jul;36(7):953-61. doi: 10.1088/0031-9155/36/7/004.
A reconstructed separate fat image was used for studying the fat content of the liver of 12 dead and six living fasting burbots (Lota lota) in a 0.04 T magnetic field with olive oil as a reference. The correlation between the MR intensities and the results of the cytological, histological and chemical fat measurements, as well as chemically measured water, collagen and total protein contents were examined. The MR signal intensity in reconstructed fat images correlated well with the changes in fat content of the liver in living fish (r = 0.69, P = 0.0014). Also the contents of water (r = -0.66, P = 0.003) and total protein (r = -0.91, P = 0.013) correlated significantly with the MR signal intensity. The reconstructed fat image is thus a reliable method for following the changes in tissue fat content. The living burbot is an applicable test animal for studying the hepatic fat content with MR.
利用重建的单独脂肪图像，以橄榄油为参考，在0.04 T磁场中研究了12只死亡和6只活体禁食江鳕（Lota lota）肝脏的脂肪含量。检测了磁共振强度与细胞学、组织学及化学脂肪测量结果之间的相关性，以及化学测量的水、胶原蛋白和总蛋白含量。重建脂肪图像中的磁共振信号强度与活鱼肝脏脂肪含量的变化相关性良好（r = 0.69，P = 0.0014）。水含量（r = -0.66，P = 0.003）和总蛋白含量（r = -0.91，P = 0.013）也与磁共振信号强度显著相关。因此，重建脂肪图像是跟踪组织脂肪含量变化的可靠方法。活体江鳕是利用磁共振研究肝脏脂肪含量的适用实验动物。
