Komu M, Alanen A
Department of Diagnostic Radiology, University of Turku, Finland.
Physiol Meas. 1994 Aug;15(3):243-50. doi: 10.1088/0967-3334/15/3/002.
The magnetization transfer technique was applied to imaging of liver tissue at 0.1 T in order to examine the dependence of proton relaxation parameters on protein concentration. The effect of the fat signal on the values of these parameters was also evaluated by using the special fat/water separation method for low fields. The livers of pigs as a model for low-fat tissue and those of burbots as a model for fatty tissue were examined. For the low-fat liver tissue, the magnetization transfer rate Rwm correlated linearly with the total protein concentration very significantly (p = 0.0086). For the fatty liver, the relaxation parameters did not correlate well with the total protein concentration. After fat/water separation, the relaxation times T1 and T1w, the magnetization transfer rate Rwm and magnetization transfer contrast (MTC), measured from the water image, increased significantly. This indicates that the presence of fat in the liver will affect the measured values of magnetization transfer parameters.
为了研究质子弛豫参数对蛋白质浓度的依赖性，采用磁化传递技术在0.1 T磁场下对肝脏组织进行成像。还使用低场专用脂肪/水分离方法评估了脂肪信号对这些参数值的影响。以猪的肝脏作为低脂组织模型，以江鳕的肝脏作为脂肪组织模型进行研究。对于低脂肝脏组织，磁化传递率Rwm与总蛋白浓度呈非常显著的线性相关（p = 0.0086）。对于脂肪肝，弛豫参数与总蛋白浓度的相关性不佳。进行脂肪/水分离后，从水图像测量得到的弛豫时间T1和T1w、磁化传递率Rwm和磁化传递对比度（MTC）显著增加。这表明肝脏中脂肪的存在会影响磁化传递参数的测量值。
