Strunk R C, John T J, Sieber O F
Infect Immun. 1977 Jan;15(1):165-8. doi: 10.1128/iai.15.1.165-168.1977.
Separate groups of normal and C4-deficient guinea pigs were inoculated with herpes simplex virus by intradermal (i.d.) and intraperitoneal (i.p.) routes. Virus infection, confirmed by clinical, virological, and serological criteria, did not last longer and was not more severe in C4-deficient guinea pigs than in normal guinea pigs. Serum C component levels were measured before, during, and after herpes simplex virus infection. In normal gruinea pigs there was no evidence for C4 utilization after either i.d. or i.p. inoculation. In both normal and C4-deficient guinea pigs, C1 and C3-9 levels remained unchanged in spite of i.d. or i.p. infection. These data suggested that C4 and the classical C pathway were not important for virus clearance.
将正常豚鼠和C4缺陷型豚鼠分成不同组，通过皮内（i.d.）和腹腔内（i.p.）途径接种单纯疱疹病毒。根据临床、病毒学和血清学标准确诊的病毒感染，在C4缺陷型豚鼠中持续时间并不比正常豚鼠更长，严重程度也不比正常豚鼠更高。在单纯疱疹病毒感染前、感染期间和感染后测量血清补体成分水平。在正常豚鼠中，无论是皮内接种还是腹腔内接种后，均没有证据表明C4被利用。在正常豚鼠和C4缺陷型豚鼠中，尽管有皮内或腹腔内感染，C1和C3 - 9水平均保持不变。这些数据表明，C4和经典补体途径对病毒清除并不重要。
