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携带2型单纯疱疹病毒诱导肿瘤的仓鼠血清中C2和C4的消耗。

Depletion of C2 and C4 in sera from hamsters bearing herpes simplex type 2-induced tumors.

作者信息

Márquez E D

出版信息

Immunol Commun. 1980;9(6):569-75. doi: 10.3109/08820138009052996.

DOI:10.3109/08820138009052996
PMID:7429530
Abstract

Total hemolytic complement activity (CH50) was compared in sera from normal and tumor-bearing hamsters. CH50 ranged from 160-216 in normal animals and from 82 to 152 in tumor-bearing animals. Preliminary screening assays indicated that of 9 complement components assayed, only C2 and C4 showed differences in titer in both normal and tumor-bearer sera. In an expanded study, examination of sera from 12 normal and 14 tumor-bearing hamsters showed that the mean C4 and C2 levels were approximately 88 and 70% below those seen in normal sera, respectively.

摘要

比较了正常仓鼠和荷瘤仓鼠血清中的总溶血补体活性(CH50)。正常动物的CH50范围为160 - 216,荷瘤动物的CH50范围为82至152。初步筛选试验表明,在所检测的9种补体成分中,只有C2和C4在正常血清和荷瘤血清中的滴度存在差异。在一项扩展研究中,对12只正常仓鼠和14只荷瘤仓鼠的血清进行检测,结果显示,C4和C2的平均水平分别比正常血清中的水平低约88%和70%。

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