Rooma M Ia, Kheĭnla Iu Ia, Piarn Kh M, Kann E M
Vopr Onkol. 1991;37(4):465-70.
The study assessed excretion of nitrates in urine and saliva and that of nitrites with saliva of patients suffering gastric and duodenal ulcer. In both study groups, a positive correlation was established between nitrate concentration in saliva, on the one hand, and that in urine, and nitrite level in urine, on the other. The groups failed to show a difference in nitrate concentrations in either urine or saliva. Since retention of nitrates in the body of chronic gastritis patients held as precancer of the stomach proved no higher than that in patients with duodenal ulcer, the authors cast doubt on endogenous nitroso compounds as a cause of gastric cancer in cases of chronic gastritis.
该研究评估了胃溃疡和十二指肠溃疡患者尿液和唾液中硝酸盐的排泄情况以及唾液中亚硝酸盐的排泄情况。在两个研究组中,一方面唾液中硝酸盐浓度与尿液中硝酸盐浓度之间,另一方面与尿液中亚硝酸盐水平之间均建立了正相关关系。两组在尿液或唾液中的硝酸盐浓度上均未显示出差异。由于被视为胃癌前期的慢性胃炎患者体内硝酸盐的潴留情况并不高于十二指肠溃疡患者,因此作者对慢性胃炎病例中内源性亚硝基化合物作为胃癌病因表示怀疑。