Chen V W, Abu-Elyazeed R R, Zavala D E, Haenszel W, Ktsanes V K, Rice J, Cuello C, Montes G, Correa P
Department of Pathology, Louisiana State University Medical Center, New Orleans 70112.
Nutr Cancer. 1990;13(1-2):67-72. doi: 10.1080/01635589009514046.
Gastric nitrite content was studied in relation to precancerous lesions of the stomach in a case-control study conducted in a high-risk Colombian population. The proportion of detectable nitrite in gastric juice and the mean pH were significantly higher among those with precancerous lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia) than among the controls (normal and superficial gastritis); the proportion and mean pH increased with the progression of histological changes from normal to dysplasia. Nitrite was not detectable in gastric juice with a pH less than 5.0. A positive association was found between the proportion of detectable nitrite and the risk of gastric precancerous lesions. Odds ratios of 4.39 for intestinal metaplasia and 24.72 for dysplasia remained significant after controlling for confounders. This finding suggests that nitrite may be a precursor of a mutagen that targets gastric epithelial cells.
在一项针对哥伦比亚高危人群开展的病例对照研究中，对胃内亚硝酸盐含量与胃部癌前病变的关系进行了研究。与对照组（正常和浅表性胃炎）相比，患有癌前病变（慢性萎缩性胃炎、肠化生和发育异常）者胃液中亚硝酸盐可检出比例及平均pH值显著更高；随着组织学变化从正常发展到发育异常，该比例及平均pH值升高。pH值小于5.0的胃液中未检测到亚硝酸盐。亚硝酸盐可检出比例与胃部癌前病变风险之间存在正相关。在控制混杂因素后，肠化生的优势比为4.39，发育异常的优势比为24.72，差异仍具有统计学意义。这一发现表明，亚硝酸盐可能是一种靶向胃上皮细胞的诱变剂的前体。
