Beno I, Sigmundová V
Výskumný ústav výzivy v Bratislave a Národný ústav hygieny a epidemiológie v Bratislave, Slovakia.
Bratisl Lek Listy. 1993 Oct;94(10):531-5.
Atrophic gastritis is precancerous condition of the intestinal type of gastric carcinoma. This process supposes a genotoxic effect of N-nitroso-compounds which are formed in the stomach by nitrosation of nitrites and organic nitrogen compounds. The authors examined 41 patients with chronic superficial and atrophic gastritis. They examined the pH and concentration of nitrates and nitrites in gastric juice taken in the morning before meal. They discovered that in severe atrophic gastritis the amount of nitrates is significantly increased and the amount of nitrites is decreased, all in comparison with superficial gastritis. An exponential relation of the concentration of nitrites towards the pH of gastric juice was found to be NO2- = epH-6.5, CC = 0.935. A significant elevation of nitrite concentration was observed in cases of pH being higher than 5.5. Nitrate concentration altered in dependence of the value of gastric pH. Oral administration of 300 mg of vitamin C or 250 mg of vitamin E did not significantly affect the amount of gastric nitrites. The work discusses the mutual relation of nitrites, ascorbic acid and alpha-tocopherol towards the formation of N-nitroso-compounds in the stomach inflicted by atrophic gastritis. (Tab. 3, Fig. 2, Ref. 25.)
萎缩性胃炎是肠型胃癌的癌前病变。这一过程推测是由亚硝酸盐和有机氮化合物在胃中通过亚硝化作用形成的N-亚硝基化合物的基因毒性作用所致。作者检查了41例慢性浅表性和萎缩性胃炎患者。他们检测了早餐前采集的胃液的pH值以及硝酸盐和亚硝酸盐的浓度。他们发现，与浅表性胃炎相比，重度萎缩性胃炎患者的硝酸盐含量显著增加，亚硝酸盐含量降低。发现亚硝酸盐浓度与胃液pH值呈指数关系，即NO2- = epH-6.5，CC = 0.935。在pH值高于5.5的情况下，观察到亚硝酸盐浓度显著升高。硝酸盐浓度随胃pH值的变化而改变。口服300毫克维生素C或250毫克维生素E对胃内亚硝酸盐含量没有显著影响。该研究探讨了亚硝酸盐、抗坏血酸和α-生育酚在萎缩性胃炎所致胃内N-亚硝基化合物形成过程中的相互关系。（表3，图2，参考文献25）
