BENNETT I L
J Exp Med. 1948 Sep 1;88(3):267-78. doi: 10.1084/jem.88.3.267.
The relationship between the fever of acute infection and that following injection of bacterial pyrogen was studied by administering pyrogens to animals convalescent from acute infections. Rabbits surviving dermal pneumococcal infections or peritonitis due to Escherichia coli were given intravenous injections of typhoid or E. coli vaccine. They showed no evidence of tolerance to the fever-promoting effect of these pyrogenic materials. Tolerance did develop in infected animals given daily pyrogen injections during the course of the infection. Certain previous observations upon the ability of rabbits to develop tolerance to pyrogens, the broad nature of the tolerance, and its duration were confirmed. It is concluded that the pyrogen produced by certain bacteria plays little or no rôle in the production of the fever of infection. These findings are compatible with the hypothesis that there is a common factor, perhaps a product of cell injury, underlying the fever accompanying diseases of various types.
通过给急性感染康复期的动物注射热原,研究了急性感染发热与注射细菌热原后发热之间的关系。给患皮肤肺炎球菌感染或因大肠杆菌引起的腹膜炎后存活的兔子静脉注射伤寒疫苗或大肠杆菌疫苗。它们没有表现出对这些热原性物质促热作用产生耐受性的迹象。在感染过程中每天给感染动物注射热原,确实会产生耐受性。先前关于兔子产生热原耐受性的能力、耐受性的广泛性质及其持续时间的某些观察结果得到了证实。得出的结论是,某些细菌产生的热原在感染发热的产生中作用很小或不起作用。这些发现与以下假设相符,即存在一个共同因素,可能是细胞损伤的产物,是各种类型疾病伴随发热的基础。