BENNETT I L
J Exp Med. 1948 Sep 1;88(3):279-84. doi: 10.1084/jem.88.3.279.
The relationship of the fever caused in rabbits by bacterial pyrogens to the fever produced by the injection of the sterile exudates of acute inflammation was investigated by recording the responses of normal and pyrogen-tolerant animals to injections of exudate. Exudates were produced by the intrapleural injection of turpentine in dogs. The duration of the febrile response in rabbits after a single dose of exudate was found to be much shorter than the fever following an injection of bacterial pyrogen. Animals given daily injections of exudate demonstrated no tolerance to its fever-promoting effect. Animals tolerant to bacterial pyrogens showed no diminution in responsiveness to exudates. Daily injections of exudate failed to establish tolerance to bacterial pyrogens in rabbits. It is concluded that the fever-promoting property of sterile exudates is not due to the presence of bacterial pyrogen.
通过记录正常动物和对热原耐受的动物对渗出液注射的反应,研究了细菌热原在兔子身上引起的发热与注射急性炎症无菌渗出液所产生的发热之间的关系。渗出液是通过在狗的胸膜腔内注射松节油产生的。发现单剂量渗出液后兔子发热反应的持续时间比注射细菌热原后的发热持续时间短得多。每天注射渗出液的动物对其促热作用没有耐受性。对细菌热原耐受的动物对渗出液的反应性没有降低。每天注射渗出液未能使兔子对细菌热原产生耐受性。得出的结论是,无菌渗出液的促热特性不是由于细菌热原的存在。