恒河猴实验性急性播散性脑脊髓炎的研究；补体结合抗体。
Studies on acute disseminated encephalomyelitis produced experimentally in Rhesus monkeys; complement-fixing antibodies.
作者信息
LUMSDEN C E, KABAT E A, WOLF A, BEZER A E
出版信息
J Exp Med. 1950 Sep;92(3):253-70. doi: 10.1084/jem.92.3.253.
Abstract
- Animals injected with emulsions of monkey brain with adjuvants show a complex pattern of antibody response as determined by complement fixation tests. 2. Organ-specific complement-fixing antibodies to constituents of brain tissue may be formed which fix complement with brain tissues of various animal species but fail to react with other organs or with rabbit placenta. 3. Antibodies may be formed to some constituent of brain other than nervous tissue. It would seem that these can be detected by the strong complement fixation given with rabbit placenta. 4. Sera from individual animals may contain antibodies to the brain or placenta constituents, to both, or to neither. Occasional individual sera show unique patterns of antibody response as determined with various additional antigens such as fetal brain, posterior pituitary, or peripheral nerves. 5. No evidence of any etiological relationship between the development of encephalomyelitis and the complement-fixing antibodies to brain demonstrable in the sera could be found. The complement-fixing antibody to the placental constituent was unrelated to the encephalomyelitis.
摘要
- 通过补体结合试验测定，注射了含有佐剂的猴脑乳剂的动物呈现出复杂的抗体反应模式。2. 可能会形成针对脑组织成分的器官特异性补体结合抗体，这些抗体能与多种动物物种的脑组织结合补体，但不能与其他器官或兔胎盘发生反应。3. 可能会形成针对神经组织以外的某些脑成分的抗体。似乎可以通过与兔胎盘产生的强烈补体结合来检测到这些抗体。4. 单个动物的血清可能含有针对脑或胎盘成分的抗体、同时含有这两种抗体或两者都不含有。偶尔，个别血清会呈现出独特的抗体反应模式，这是通过使用各种其他抗原（如胎儿脑、垂体后叶或外周神经）测定得出的。5. 未发现血清中可检测到的针对脑的补体结合抗体与脑脊髓炎的发生之间存在任何病因学关系。针对胎盘成分的补体结合抗体与脑脊髓炎无关。
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