Li Y
Third Clinical College of Zhongshan University of Medical Sciences, Guangzhou.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;26(3):135-7, 188.
The histology and surface ultrastructures of the nasal mucosa and adrenal after intranasal beclomethasone dipropionate (BDP) 400mg/day for 5 weeks were observed with light and scanning electron microscopes in rabbits. Besides, the ciliary activities in vitro and mucociliary transportation function in frog oral mucosa after administrating BDP were studied. The results showed that intranasal BDP did not produce significant lesions of the nasal mucosa and atrophy of the adrenal in rabbits and BDP did not reduce oral mucociliary activities in frog. It suggests that intranasal BDP therapy is safe.
用光学显微镜和扫描电子显微镜观察了家兔每天经鼻给予400mg丙酸倍氯米松（BDP），持续5周后鼻黏膜和肾上腺的组织学及表面超微结构。此外，还研究了给予BDP后青蛙口腔黏膜的体外纤毛活动和黏液纤毛转运功能。结果表明，经鼻给予BDP对家兔鼻黏膜无明显损伤，对肾上腺无萎缩作用，且BDP不降低青蛙口腔黏液纤毛活动。这表明经鼻BDP治疗是安全的。
