Holmberg K, Pipkorn U
Eur J Clin Pharmacol. 1986;30(5):625-7. doi: 10.1007/BF00542425.
The local effect of an aqueous suspension of beclomethasone dipropionate on human nasal mucociliary clearance was studied in 14 healthy volunteers. A triple blind, randomized, placebo controlled, cross-over design was utilised. Measurements of mucociliary clearance were made before treatment, after a single dose and after one week of continuous treatment either with placebo or active substance, utilising the saccharine-dye test. No change in mucociliary clearance was found after treatment with beclomethasone dipropionate or placebo suspension.
在14名健康志愿者中研究了丙酸倍氯米松水混悬液对人鼻黏膜纤毛清除功能的局部作用。采用三盲、随机、安慰剂对照、交叉设计。在治疗前、单剂量给药后以及用安慰剂或活性物质连续治疗一周后，使用糖精-染料试验测量黏膜纤毛清除功能。使用丙酸倍氯米松或安慰剂混悬液治疗后，未发现黏膜纤毛清除功能有变化。
