Hagenfeldt Y, Carlström K, Berlin T, Stege R
Department of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Sweden.
J Steroid Biochem Mol Biol. 1991 Aug;39(2):155-9. doi: 10.1016/0960-0760(91)90056-b.
Serum levels of total 1,25-dihydroxyvitamin D (1,25(OH)2D), vitamin D binding protein (DBP), sex hormone binding globulin (SHBG), testosterone, estradiol 17 beta (E2) and the "free" 1,25(OH)2D index were measured before and during treatment in prostatic cancer patients treated by orchidectomy (n = 15), with combined i.m. polyestradiol phosphate (PEP) + oral ethinyl estradiol (EE) (n = 10) and with i.m. PEP only for 3 months, followed by addition of oral EE (n = 9). Total concentrations of 1,25(OH)2D and DBP were unaffected by orchidectomy and treatment with i.m. PEP only, but were significantly elevated during treatment including oral EE. SHBG levels were unaffected by orchidectomy, slightly increased by i.m. PEP only and greatly increased by oral EE. The free 1,25(OH)2D index was slightly elevated by treatment including oral EE. Evidence was obtained that the increase in 1,25(OH)2D levels observed during oral estrogen treatment was secondary to the estrogen-augmented increase in DBP and not a result of an estrogen-stimulated synthesis of 1,25(OH)2D. Furthermore, the stimulatory effect of estrogen on DBP concentrations seemed to be dependent on the route of administration of the hormone.
在接受睾丸切除术（n = 15）、联合肌肉注射聚磷酸雌二醇（PEP）+口服炔雌醇（EE）（n = 10）以及仅肌肉注射PEP 3个月后加用口服EE（n = 9）治疗的前列腺癌患者中，在治疗前和治疗期间测量了血清总1,25 - 二羟基维生素D（1,25(OH)2D）、维生素D结合蛋白（DBP）、性激素结合球蛋白（SHBG）、睾酮、雌二醇17β（E2）以及“游离”1,25(OH)2D指数。1,25(OH)2D和DBP的总浓度不受睾丸切除术和仅肌肉注射PEP治疗的影响，但在包括口服EE的治疗期间显著升高。SHBG水平不受睾丸切除术影响，仅肌肉注射PEP使其略有升高，口服EE则使其大幅升高。包括口服EE的治疗使游离1,25(OH)2D指数略有升高。有证据表明，口服雌激素治疗期间观察到的1,25(OH)2D水平升高是DBP因雌激素增加所致，而非雌激素刺激1,25(OH)2D合成的结果。此外，雌激素对DBP浓度的刺激作用似乎取决于激素的给药途径。
