Eriksson S, Eriksson A, Stege R, Carlström K
Department of Orthopedics, Karolinska Institutet, Huddinge University Hospital, Sweden.
Calcif Tissue Int. 1995 Aug;57(2):97-9. doi: 10.1007/BF00298427.
Bone mineral density (BMD) and bone mineral content (BMC) were measured in the femoral neck area, trochanteric area and Wards triangle, and in the distal radius of the left forearm before and after 1 year of endocrine treatment in 27 patients with prostatic cancer. Eleven of the patients were treated with orchidectomy and 16 with combined oral and intramuscular estrogens. The patients were free from metastases during the entire observation period. In the orchidectomized patients, BMD and BMC of the distal radius decreased significantly following treatment, whereas no changes were observed in the estrogen-treated patients. These preliminary results demonstrate that estrogens may protect bone in male subjects also and may merit further investigations on larger groups of patients.
对27例前列腺癌患者在进行1年内分泌治疗前后，测量其股骨颈区域、转子区和沃德三角区以及左前臂桡骨远端的骨密度（BMD）和骨矿物质含量（BMC）。其中11例患者接受了睾丸切除术，16例接受了口服和肌肉注射雌激素联合治疗。在整个观察期内，患者均无转移。在接受睾丸切除术的患者中，治疗后桡骨远端的BMD和BMC显著下降，而接受雌激素治疗的患者未观察到变化。这些初步结果表明，雌激素也可能对男性骨骼有保护作用，值得对更多患者群体进行进一步研究。
