Rutherford O M, Jones D A, Round J M, Buchanan C R, Preece M A
Department of Medicine, University College, London, UK.
Clin Endocrinol (Oxf). 1991 Jun;34(6):469-75. doi: 10.1111/j.1365-2265.1991.tb00327.x.
The aim of this study was to determine whether there are any changes in skeletal muscle strength and size and body composition following growth hormone (GH) withdrawal in GH deficient young adults.
A longitudinal, 1-year, open, uncontrolled study of the changes in skeletal muscle and body composition following GH withdrawal was performed. Endocrine status was reassessed at the end of the study period during an insulin tolerance test. Some measurements were repeated after 2 years of treatment.
Twelve (11 male, one female; age range 14-21) patients who had been diagnosed during childhood as growth hormone deficient took part in the study. Four of the 12 patients were found to have a normal GH response on retesting at the end of the study and their results were analysed as a separate group.
Quadriceps and forearm flexor maximum voluntary isometric strength, body fat content and serum IGF-1 were measured at 3-monthly intervals over 1 year. Every 6 months muscle size was measured from computerized tomography scans and fibre area from quadriceps needle biopsy samples.
For the growth hormone deficient group the 12 month quadriceps strength, size and fibre areas were 94.0% +/- 8.5 (mean +/- SD), 94.5% +/- 6.3 and 85.6% +/- 17.7 respectively of control (baseline) values. Forearm flexor strength and size were 101.4% +/- 7.9 and 92.0% +/- 9.2 of control. Body fat percentage had increased from 19.5% +/- 8.6 to 24.1% +/- 9.5. No change was seen in the non-growth hormone deficient group.
Although the changes measured were relatively small they suggest a role for GH in the maintenance of muscle integrity and body composition in the young adult with growth hormone deficiency.
本研究旨在确定生长激素缺乏的年轻成年人停用生长激素（GH）后，其骨骼肌力量、大小及身体成分是否会发生变化。
进行了一项为期1年的纵向、开放性、非对照研究，观察停用GH后骨骼肌及身体成分的变化。在研究期末的胰岛素耐量试验期间重新评估内分泌状态。治疗2年后重复进行了一些测量。
12名（11名男性，1名女性；年龄范围14 - 21岁）童年期被诊断为生长激素缺乏的患者参与了本研究。12名患者中有4名在研究结束时重新检测发现GH反应正常，其结果作为一个单独的组进行分析。
在1年时间里，每隔3个月测量一次股四头肌和前臂屈肌的最大随意等长肌力、体脂含量及血清胰岛素样生长因子-1（IGF-1）。每6个月通过计算机断层扫描测量肌肉大小，并从股四头肌针吸活检样本中测量纤维面积。
对于生长激素缺乏组，12个月时股四头肌力量、大小及纤维面积分别为对照组（基线）值的94.0%±8.5（均值±标准差）、94.5%±6.3和85.6%±17.7。前臂屈肌力量和大小分别为对照组的101.4%±7.9和92.0%±9.2。体脂百分比从19.5%±8.6增加到了24.1%±9.5。非生长激素缺乏组未见变化。
尽管所测变化相对较小，但提示GH在维持生长激素缺乏的年轻成年人的肌肉完整性和身体成分方面发挥作用。
