Rutherford O M, Jones D A, Round J M, Preece M A
Department of Medicine, Rayne Institute, University College, London, UK.
Acta Paediatr Scand Suppl. 1989;356:61-3; discussion 64, 73-4. doi: 10.1111/j.1651-2227.1989.tb11244.x.
Skeletal muscle strength and size were measured for 1 year following discontinuation of human growth hormone (hGH) treatment in 11 patients with hypopituitarism. Quadriceps and forearm flexor maximum voluntary isometric strength and size were measured. At the end of the study, endocrine status was reassessed by an insulin tolerance test. Three of the 11 subjects were found to have normal hGH secretion and were not included in the analysis. At 12 months, quadriceps strength, size and fibre areas were 94.0 +/- 8.5%, 94.5 +/- 6.3% and 85.6 +/- 17.7% (mean +/- SD), respectively, of baseline values. Forearm flexor strength and size were 101.4 +/- 7.9% and 92 +/- 9.2% of control values. Although these changes are relatively small, they suggest a role for growth hormone in the maintenance of muscle in the adult.
对11例垂体功能减退患者停用人生长激素（hGH）治疗后1年的骨骼肌力量和大小进行了测量。测量了股四头肌和前臂屈肌的最大自主等长力量和大小。在研究结束时，通过胰岛素耐量试验重新评估内分泌状态。11名受试者中有3人hGH分泌正常，未纳入分析。在12个月时，股四头肌力量、大小和纤维面积分别为基线值的94.0±8.5%、94.5±6.3%和85.6±17.7%（平均值±标准差）。前臂屈肌力量和大小分别为对照值的101.4±7.9%和92±9.2%。虽然这些变化相对较小，但它们表明生长激素在维持成年人肌肉方面发挥了作用。
