Raizman M B, Sainz de la Maza M, Foster C S
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114.
Cornea. 1991 Jul;10(4):312-6. doi: 10.1097/00003226-199107000-00006.
Peripheral ulcerative keratitis (PUK) is a destructive, inflammatory process that can lead to corneal perforation and visual loss. Successful control of PUK has been reported with conjunctival resection, cyanoacrylate adhesive, and systemic immunosuppression. Cases with impending or actual corneal perforation may require more extensive surgery, including lamellar or penetrating keratoplasty, to maintain the integrity of the globe. We report on 17 eyes of 14 patients with PUK that required tectonic keratoplasty because of progressive ulceration. Surgery with concomitant immunosuppression preserved the eyes in all but two cases, and 8 of 17 eyes maintained or improved preoperative visual acuity. Six eyes had final visual acuities of 20/200 or better. This therapeutic strategy can preserve eyes that might otherwise be lost to progressive inflammation.
周边溃疡性角膜炎（PUK）是一种破坏性的炎症过程，可导致角膜穿孔和视力丧失。据报道，通过结膜切除术、氰基丙烯酸酯粘合剂和全身免疫抑制可成功控制PUK。对于即将发生或已发生角膜穿孔的病例，可能需要更广泛的手术，包括板层或穿透性角膜移植术，以维持眼球的完整性。我们报告了14例PUK患者的17只眼，这些眼因溃疡进展需要进行结构性角膜移植术。除两例外，所有病例在手术同时进行免疫抑制均保住了眼球，17只眼中有8只维持或提高了术前视力。6只眼的最终视力达到20/200或更好。这种治疗策略可以保住那些否则可能因进行性炎症而失明的眼睛。
