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在无甲泼尼龙情况下使用TAO治疗重度哮喘。

Use of TAO without methylprednisolone in the treatment of severe asthma.

作者信息

Rosenberg S M, Gerhard H, Grunstein M M, Schramm C M

机构信息

Division of Pulmonary Medicine, Children's Hospital of Philadelphia.

出版信息

Chest. 1991 Sep;100(3):849-50. doi: 10.1378/chest.100.3.849.

DOI:10.1378/chest.100.3.849
PMID:1889284
Abstract

The antimicrobial agent troleandomycin (TAO) has been shown to be effective in reducing corticosteroid requirements in patients with corticosteroid-dependent asthma. To our knowledge, the efficacy of TAO without concomitant use of corticosteroids has never been documented. We report the case of a 12-year-old patient with corticosteroid-dependent asthma who has remained asymptomatic and without any evidence of pulmonary deterioration during treatment with TAO without concomitant use of corticosteroids.

摘要

抗菌药物曲古霉素(TAO)已被证明在减少依赖皮质类固醇激素的哮喘患者对皮质类固醇激素的需求方面有效。据我们所知,从未有文献记载TAO在不联合使用皮质类固醇激素时的疗效。我们报告了一例12岁依赖皮质类固醇激素的哮喘患者,该患者在使用TAO且未联合使用皮质类固醇激素治疗期间一直无症状,且无任何肺部恶化的迹象。

相似文献

1
Use of TAO without methylprednisolone in the treatment of severe asthma.在无甲泼尼龙情况下使用TAO治疗重度哮喘。
Chest. 1991 Sep;100(3):849-50. doi: 10.1378/chest.100.3.849.
2
The incidence of corticosteroid side effects in chronic steroid-dependent asthmatics on TAO (troleandomycin) and methylprednisolone.在长期依赖类固醇的哮喘患者中,使用醋竹桃霉素(TAO)和甲基强的松龙时皮质类固醇副作用的发生率。
Ann Allergy. 1989 Aug;63(2):110-1.
3
Dose- and time-related effect of troleandomycin on methylprednisolone elimination.三乙酰竹桃霉素对甲基泼尼松龙消除的剂量及时间相关效应。
Clin Pharmacol Ther. 1982 Aug;32(2):166-71. doi: 10.1038/clpt.1982.143.
4
Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma.曲古霉素治疗重度、依赖皮质类固醇的门诊哮喘患者的疗效
J Allergy Clin Immunol. 1980 Dec;66(6):438-46. doi: 10.1016/0091-6749(80)90003-2.
5
Troleandomycin in the treatment of difficult asthma.三乙酰竹桃霉素治疗难治性哮喘
J Allergy Clin Immunol. 1993 Nov;92(5):677-82. doi: 10.1016/0091-6749(93)90010-d.
6
Effect of low-dose troleandomycin on glucocorticoid pharmacokinetics and airway hyperresponsiveness in severely asthmatic children.小剂量醋竹桃霉素对重度哮喘患儿糖皮质激素药代动力学及气道高反应性的影响
Ann Allergy. 1990 Jul;65(1):37-45.
7
An improved protocol for the use of troleandomycin (TAO) in the treatment of steroid-requiring asthma.
J Allergy Clin Immunol. 1986 Jul;78(1 Pt 1):36-43. doi: 10.1016/0091-6749(86)90112-0.
8
A double-blind study of troleandomycin and methylprednisolone in asthmatic subjects who require daily corticosteroids.一项针对需要每日使用皮质类固醇的哮喘患者的双盲研究,比较了曲安西龙和甲基强的松龙的疗效。
Am Rev Respir Dis. 1993 Feb;147(2):398-404. doi: 10.1164/ajrccm/147.2.398.
9
[Experiences with a combination therapy of methylprednisolone and troleandomycin in severe bronchial asthma requiring high-dose corticoids].[甲泼尼龙与醋竹桃霉素联合治疗需大剂量皮质激素的重度支气管哮喘的经验]
Pneumologie. 1990 Feb;44 Suppl 1:238-40.
10
Steroid-specific and anticonvulsant interaction aspects of troleandomycin-steroid therapy.三乙酰竹桃霉素-类固醇疗法的类固醇特异性及抗惊厥相互作用方面
J Allergy Clin Immunol. 1982 May;69(5):455-60. doi: 10.1016/0091-6749(82)90121-x.

引用本文的文献

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Mechanisms of action and clinical application of macrolides as immunomodulatory medications.大环内酯类作为免疫调节药物的作用机制和临床应用。
Clin Microbiol Rev. 2010 Jul;23(3):590-615. doi: 10.1128/CMR.00078-09.
2
Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?吸入性糖皮质激素和大环内酯类药物疗法在支气管扩张症中起作用吗?
Drugs. 2007;67(7):965-74. doi: 10.2165/00003495-200767070-00002.
3
Immunomodulatory effects of macrolide antibiotics in respiratory disease: therapeutic implications for asthma and cystic fibrosis.
大环内酯类抗生素在呼吸道疾病中的免疫调节作用:对哮喘和囊性纤维化的治疗意义。
Paediatr Drugs. 2007;9(2):107-18. doi: 10.2165/00148581-200709020-00004.
4
Low-dose, long-term macrolide therapy in asthma: An overview.哮喘的低剂量长期大环内酯类药物治疗:综述
Clin Mol Allergy. 2004 Mar 16;2(1):4. doi: 10.1186/1476-7961-2-4.
5
Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma.三乙酰竹桃霉素作为稳定期哮喘中一种口服糖皮质激素节省剂。
Cochrane Database Syst Rev. 2001;2000(2):CD002987. doi: 10.1002/14651858.CD002987.
6
The anti-inflammatory effects of macrolides.大环内酯类药物的抗炎作用。
Thorax. 1999 Aug;54 Suppl 2(Suppl 2):S58-62. doi: 10.1136/thx.54.2008.s58.
7
Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils.大环内酯类药物与人中性粒细胞的膜稳定、抗炎相互作用。
Inflammation. 1996 Dec;20(6):693-705. doi: 10.1007/BF01488805.