哮喘的低剂量长期大环内酯类药物治疗：综述
Low-dose, long-term macrolide therapy in asthma: An overview.
作者信息
Hatipoglu Umur, Rubinstein Israel
机构信息
Section of Respiratory and Critical Care Medicine, Department of Medicine and Department of Biopharmaceutical Sciences, Colleges of Medicine and Pharmacy, University of Illinois at Chicago, and VA Chicago Health Care System, Chicago, Illinois 60612, U,S,A.
出版信息
Clin Mol Allergy. 2004 Mar 16;2(1):4. doi: 10.1186/1476-7961-2-4.
Abstract
Macrolides, a class of antimicrobials isolated from Streptomycetes more than 50 years ago, are used extensively to treat sinopulmonary infections in humans. In addition, a growing body of experimental and clinical evidence indicates that long-term (years), low (sub-antimicrobial)-dose 14- and 15-membered ring macrolide antibiotics, such as erythromycin, clarithromycin, roxithromycin and azithromycin, express immunomodulatory and tissue reparative effects that are distinct from their anti-infective properties. These salutary effects are operative in various lung disorders, including diffuse panbronchiolitis, cystic fibrosis, persistent chronic rhinosinusitis, nasal polyposis, bronchiectasis, asthma and cryptogenic organizing pneumonia.The purpose of this overview is to outline the immunomodulatory effects of macrolide antibiotics in patients with asthma.
摘要
大环内酯类药物是50多年前从链霉菌中分离出的一类抗菌药物，广泛用于治疗人类的鼻窦肺部感染。此外，越来越多的实验和临床证据表明，长期（数年）、低（亚抗菌）剂量的14元和15元环大环内酯类抗生素，如红霉素、克拉霉素、罗红霉素和阿奇霉素，具有不同于其抗感染特性的免疫调节和组织修复作用。这些有益作用在各种肺部疾病中都有作用，包括弥漫性泛细支气管炎、囊性纤维化、持续性慢性鼻窦炎、鼻息肉病、支气管扩张、哮喘和隐源性机化性肺炎。本综述的目的是概述大环内酯类抗生素对哮喘患者的免疫调节作用。
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