Szefler S J, Brenner M, Jusko W J, Spector S L, Flesher K A, Ellis E F
Clin Pharmacol Ther. 1982 Aug;32(2):166-71. doi: 10.1038/clpt.1982.143.
Effects of varying doses of troleandomycin (TAO) on methylprednisolone disposition were examined in five steroid-dependent asthmatic patients. The characteristic reduction in methylprednisolone elimination in the presence of TAO after a 40 mg IV methylprednisolone was also present after methylprednisolone doses as low as 4 mg. In patients receiving continuous TAO on an every-other-day basis, inhibition of methylprednisolone elimination was impaired to a greater extent on the "day on" TAO than on the "day off" TAO Methylprednisolone elimination on the day off TAO was still slower than that before TAO, however, TAO on a multiple-dose schedule resulted in greater reduction of methylprednisolone elimination than after a single TAO dose. These results suggest that TAO induces immediate and continued inhibition of methylprednisolone disposition.
在五名类固醇依赖型哮喘患者中研究了不同剂量的醋竹桃霉素（TAO）对甲泼尼龙代谢的影响。静脉注射40mg甲泼尼龙后，在TAO存在的情况下甲泼尼龙消除的特征性降低在甲泼尼龙剂量低至4mg时也存在。在每隔一天接受持续TAO治疗的患者中，与“停药日”相比，“用药日”TAO对甲泼尼龙消除的抑制作用受到更大程度的损害。然而，停药日甲泼尼龙的消除仍然比TAO治疗前慢，多剂量给药方案的TAO比单次TAO剂量后导致甲泼尼龙消除的更大程度降低。这些结果表明，TAO可立即并持续抑制甲泼尼龙的代谢。
