Rao V V, Löffler C, Hansmann I
Institut für Humangenetik, Universität Göttingen, Federal Republic of Germany.
Genomics. 1991 Jul;10(3):840-1. doi: 10.1016/0888-7543(91)90472-q.
Endothelin 3 is a novel vasoactive peptide of unique structure and belongs to the endothelin gene family. Though it mainly functions as a vasoconstrictor/pressor, it plays a major role in a wide variety of other biological functions, possibly as a novel neuropeptide. Studies with human-mouse somatic cell hybrids have suggested that the gene EDN3 is localized on human chromosome 20. We confirmed this localization and regionally mapped the gene to the region 20q13.2-q13.3.
内皮素-3是一种结构独特的新型血管活性肽，属于内皮素基因家族。尽管它主要作为血管收缩剂/升压剂发挥作用，但它可能作为一种新型神经肽，在多种其他生物学功能中起主要作用。对人-鼠体细胞杂种的研究表明，EDN3基因定位于人类20号染色体上。我们证实了这一定位，并将该基因区域定位到20q13.2-q13.3区域。
