编码锌指蛋白的两个人类基因，即ZNF 12（KOX 3）和ZNF 26（KOX 20），分别定位于7号染色体的p22 - p21和12号染色体的q24.33。
Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively.
作者信息
Seite P, Huebner K, Rousseau-Merck M F, Berger R, Thiesen H J
机构信息
INSERM U, 301 Institut de Génétique Moléculaire, Paris, France.
出版信息
Hum Genet. 1991 Apr;86(6):585-90. doi: 10.1007/BF00201545.
Two members of the human zinc finger Krüppel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12q13-qter. The zinc finger genes ZNF 12 (KOX 3) and ZNF 26 (KOX 20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites.
人类锌指蛋白克鲁ppel家族的两个成员ZNF 12（KOX 3）和ZNF 26（KOX 20），已通过体细胞杂交分析和原位染色体杂交进行了定位。小鼠-人杂交DNA中单个人类锌指基因的存在与相应细胞杂交体中特定人类染色体或染色体区域的存在相关。对这类小鼠-人杂交DNA的分析将ZNF 12（KOX 3）基因定位于染色体区域7p。ZNF 26（KOX 20）基因与染色体区域12q13-qter分离。通过原位染色体杂交，锌指基因ZNF 12（KOX 3）和ZNF 26（KOX 20）分别定位于人类染色体区域7p22-21和12q24.33。这些基因以及先前定位的ZNF 24（KOX 17）和ZNF 29（KOX 26）基因，位于脆性位点附近。
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