Fan K J, Kovi J, Earle K M
J Neuropathol Exp Neurol. 1977 Jan;36(1):41-9. doi: 10.1097/00005072-197701000-00005.
A retrospective ethnic study was made of 16,311 cases of primary central nervous system (CNS) tumors seen at the Armed Forces Institute of Pathology (AFIP), Washington, D.C., from 1958 to 1970. Results showed a considerably higher Caucasian:Negro (C:N) case ratio (13.7:1) than the C:N population ratio (8.4:1), indicating a higher relative frequency of primary CNS tumors in American Caucasians as compared to American Negroes. The glioma was significantly more frequent in Caucasians than in Negroes (p less than 0.005). In contrast, Negroes had an excess of the pituitary adenoma as compared to Caucasians (P less than 0.01). The proportional frequencies of the meningioma and the nerve sheath tumor were also higher in Negroes than in Caucasians. When this pattern of the tumor distribution of American Negroes was compared to that of African Negroes (a composite African series), the preponderance of the pituitary adenoma and the meningioma and the relative paucity of the glioma in the Negro race as compared to Caucasians were again confirmed. The differences in the relative frequency and the tumor distribution between American Negroes and Caucasians and the considerable similarity of the tumor distribution between American and African Negroes emphasize the importance of genetic factors in the development of at least some primary CNS tumors.
对1958年至1970年期间在华盛顿特区武装部队病理研究所（AFIP）所见的16311例原发性中枢神经系统（CNS）肿瘤病例进行了一项回顾性种族研究。结果显示，白种人与黑人（C:N）的病例比（13.7:1）显著高于C:N人口比（8.4:1），这表明与美国黑人相比，美国白种人原发性中枢神经系统肿瘤的相对发病率更高。胶质瘤在白种人中的发病率明显高于黑人（p<0.005）。相比之下，与白种人相比，黑人的垂体腺瘤发病率更高（P<0.01）。黑人中脑膜瘤和神经鞘瘤的比例也高于白种人。当将美国黑人的这种肿瘤分布模式与非洲黑人（一个综合的非洲系列）的模式进行比较时，再次证实了黑人种族中垂体腺瘤和脑膜瘤的优势以及与白种人相比胶质瘤的相对稀少。美国黑人和白种人在相对发病率和肿瘤分布上的差异以及美国黑人和非洲黑人在肿瘤分布上的相当相似性强调了遗传因素在至少某些原发性中枢神经系统肿瘤发生中的重要性。
