Brown Monica, Schrot Rudolph, Bauer Katrina, Letendre Deanna
Public Health Institute/California Department of Public Health, Chronic Disease Surveillance and Research Branch, 1825 Bell Street, Suite 102, Sacramento, CA 95825, USA.
J Neurooncol. 2009 Sep;94(2):249-61. doi: 10.1007/s11060-009-9864-x. Epub 2009 Apr 2.
We examined the incidence of first primary central nervous system tumors (PCNST) in California from 2001-2005. This study period represents the first five years of data collection of benign PCNST by the California Cancer Registry. California's age-adjusted incidence rates (AAIR) for malignant and benign PCNST (5.5 and 8.5 per 100,000, respectively). Malignant PCNST were highest among non-Hispanic white males (7.8 per 100,000). Benign PCNST were highest among African American females (10.5 per 100,000). Hispanics, those with the lowest socioeconomic status, and those who lived in rural California were found to be significantly younger at diagnosis. Glioblastoma was the most frequent malignant histology, while meningioma had the highest incidence among benign histologies (2.6 and 4.5 per 100,000, respectively). This study is the first in the US to compare malignant to benign PCNST using a population-based data source. It illustrates the importance of PCNST surveillance in California and in diverse communities.
我们调查了2001年至2005年加利福尼亚州原发性中枢神经系统肿瘤（PCNST）的发病率。该研究期代表了加利福尼亚癌症登记处收集良性PCNST数据的头五年。加利福尼亚州恶性和良性PCNST的年龄调整发病率（AAIR）分别为每10万人5.5例和8.5例。恶性PCNST在非西班牙裔白人男性中最高（每10万人7.8例）。良性PCNST在非裔美国女性中最高（每10万人10.5例）。西班牙裔、社会经济地位最低的人群以及居住在加利福尼亚农村地区的人群在诊断时明显更年轻。胶质母细胞瘤是最常见的恶性组织学类型，而脑膜瘤在良性组织学类型中发病率最高（分别为每10万人2.6例和4.5例）。这项研究是美国首次使用基于人群的数据源比较恶性与良性PCNST。它说明了PCNST监测在加利福尼亚州和不同社区中的重要性。
