Goldson A, Henschke U, Leffall L D, Schneider R L
J Natl Med Assoc. 1981 Aug;73(8):701-6.
The data of the Third National Cancer Survey show for many cancer types, large differences in cancer incidence between Euro-Americans and Afro-Americans.(1) As in other racial studies, it is difficult to separate environmental and genetic factors. For the cancers which are more frequent among Afro-Americans, environmental factors seem to be primarily responsible. However, among the cancers less frequent in Afro-Americans, there are some for which the racial differences have a genetic basis. This is clearly the case for skin and lip cancers caused by the ultraviolet B of the sun. Genetic factors are probably also responsible for the racial differences in the incidence of malignant melanomas, testis cancers, astrocytomas, and Ewing's sarcomas. Perhaps there is also a genetic basis for some of the racial differences in the incidence of malignant lymphomas and leukemias. For all these cancers, Afro-Americans are less susceptible. The only cancer to which Afro-Americans appear more susceptible on the basis of genetic makeup, is fibrosarcoma. This is in accord with the high frequency of keloids, a benign counterpart of fibrosarcoma in Afro-Americans.
第三次全国癌症调查的数据显示，在许多癌症类型中，欧裔美国人和非裔美国人的癌症发病率存在很大差异。（1）与其他种族研究一样，很难区分环境因素和遗传因素。对于在非裔美国人中更为常见的癌症，环境因素似乎是主要原因。然而，在非裔美国人中不太常见的癌症中，有些种族差异具有遗传基础。由太阳紫外线B引起的皮肤和唇癌显然就是这种情况。遗传因素可能也是恶性黑色素瘤、睾丸癌、星形细胞瘤和尤因肉瘤发病率种族差异的原因。也许恶性淋巴瘤和白血病发病率的一些种族差异也有遗传基础。对于所有这些癌症，非裔美国人的易感性较低。基于基因构成，非裔美国人似乎更易患的唯一癌症是纤维肉瘤。这与瘢痕疙瘩的高发病率一致，瘢痕疙瘩是纤维肉瘤在非裔美国人中的良性对应物。
