Clark C E, Smith T J
J Nutr Sci Vitaminol (Tokyo). 1976;22(4):313-9. doi: 10.3177/jnsv.22.313.
Ascorbic acid (vitamin C) prevented diphtheria toxin from inhibiting the incorporation of [U-14C]-alanine into trichloroacetic acid precipitable material in HeLa cells. Ascorbic acid did not exhibit an effect on the adenosine diphosphate-ribosylation of amino acyl transferase II nor did it separate fragment A from fragment B in "nicked" toxin. A non-specific reducing agent, para-methylaminophenol sulfate, exhibited an effect on HeLa cells very similar to the results of ascorbic acid. Citric acid, a tricarboxylic acid, had no effect on HeLa cells.
抗坏血酸（维生素C）可防止白喉毒素抑制[U-14C] -丙氨酸掺入HeLa细胞中可被三氯乙酸沉淀的物质。抗坏血酸对氨酰转移酶II的二磷酸腺苷核糖基化没有影响，也不会在“切口”毒素中将A片段与B片段分离。一种非特异性还原剂硫酸对甲氨基酚对HeLa细胞的作用与抗坏血酸的结果非常相似。三羧酸柠檬酸对HeLa细胞没有影响。
