Kojima A, Ikeuchi T, Inomata M, Shinkai T, Ishihara K, Noguchi M, Saijo N
Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
J Cancer Res Clin Oncol. 1991;117(5):479-83. doi: 10.1007/BF01612770.
Cytogenic studies were performed in a 72-year-old male patient with triple primary cancers including breast, skin and lung. Left breast cancer was diagnosed at the age of 46 and he received mastectomy and thoracic irradiation. Squamous cell carcinoma and Bowen's disease were diagnosed from two separated parts of a skin lesion at the age of 70. Small-cell lung cancer was diagnosed 1 year later, and he received chemotherapy and radiotherapy. Chromosome analysis was carried out on both peripheral lymphocyte and skin fibroblast cultures at the age of 72. Out of 30 fibroblast cells karyotyped at the second passage, 7 cells (23%) consistently showed a reciprocal translocation t(Y;6)(q12;p21). The same translocation was found in one of 200 cells from lymphocyte cultures. The findings suggest that the translocation t(Y;6) might be inherent in nature, and that the patient was a mosaic of 46,XY/46,X,t(Y;6)(q12;p21). These results highlight the constitutional chromosomal abnormality as one of the possible high-risk factors for multiple primary cancers.
对一名患有包括乳腺癌、皮肤癌和肺癌在内的三重原发性癌症的72岁男性患者进行了细胞遗传学研究。左乳腺癌于46岁时被诊断出，他接受了乳房切除术和胸部放疗。70岁时，从皮肤病变的两个不同部位诊断出鳞状细胞癌和鲍恩病。1年后诊断出小细胞肺癌，他接受了化疗和放疗。在72岁时对外周血淋巴细胞和皮肤成纤维细胞培养物进行了染色体分析。在传代培养的30个成纤维细胞中，有7个细胞（23%）始终显示出相互易位t(Y;6)(q12;p21)。在淋巴细胞培养的200个细胞中，有1个细胞发现了相同的易位。这些发现表明，易位t(Y;6)可能是先天性的，该患者是46,XY/46,X,t(Y;6)(q12;p21)的嵌合体。这些结果突出了染色体结构异常是多重原发性癌症可能的高危因素之一。
